Imagine that you have a table with a column of the type DATETIME. You’ve been storing data as localtime and after a while you need to convert these datetimes to UTC. Here’s a possible approach

UPDATE events SET start = SYS_EXTRACT_UTC(FROM_TZ(start, 'Europe/Brussels'));

You get a more generic variant using the AT TIME ZONE clause

UPDATE events SET start = FROM_TZ(start, 'Europe/Brussels') AT TIME ZONE 'America/Denver';